Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetMAP kinases and MAP kinase kinase (MEK)

Product does not compete with ATP.

General description

Synthetic. A potent mediator of inflammation that increases vascular permeability. Activates MAP kinases and MAP kinase kinase (MEK) in CHO cells.

Synthetic water-soluble platelet activating factor. A potent mediator of inflammation that increases vascular permeability. Activates MAP kinase and MAP kinase kinase (MEK) in CHO cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Honda, Z., et al. 1994. J. Biol. Chem. 269, 2307.Mori, M., et al. 1994. Ann. N.Y. Acad. Sci.744, 107.Pinckard, R.N., et al. 1992. J. Immunol.148, 3528.Salari, H., et al. 1992. Biochem. Cell Biol.70, 129.

Packaging

1 mg in Plastic ampoule

5 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C or -70°C) under an inert gas. Aqueous stock solutions are stable for up to 3 days at -20°C. Ethanol stock solutions are stable for up to 3 months at -70°C.

Warning

Toxicity: Standard Handling (A)